Ethanolamine → HCID 23114430, compound

HRID 1787301Notes

Reaction equation

HRID 1787301 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[C:13]2[O:12][CH2:11][CH:10]([C:14]3[CH:19]=[CH:18][C:17]([CH:20]([CH3:22])[CH3:21])=[CH:16][CH:15]=3)[C:9]=2[C:8]([CH3:23])=[C:7]([NH:24][C:25](=[O:32])OCC(Cl)(Cl)Cl)[C:6]=1[CH3:33].[NH2:34][CH2:35][CH2:36][OH:37]>CCCCCC.C(OCC)(=O)C>[OH:37][CH2:36][CH2:35][NH:34][C:25]([NH:24][C:7]1[C:6]([CH3:33])=[C:5]([CH2:4][CH2:3][CH2:2][OH:1])[C:13]2[O:12][CH2:11][CH:10]([C:14]3[CH:15]=[CH:16][C:17]([CH:20]([CH3:22])[CH3:21])=[CH:18][CH:19]=3)[C:9]=2[C:8]=1[CH3:23])=[O:32]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 86618061HCID 86618061, compound

Product 1

HCID 23114430HCID 23114430, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using 2,2,2-trichloroethyl (7-(3-hydroxypropyl)-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)carbamate obtained in Example 141 and 2-aminoethanol, the title compound was synthesized in the same manner as in Example 143. Yield: 53%. Melting point: 153-154° C. (hexane-ethyl acetate).

Sources & evidence

ORD record
ord-a4e480ac12b5412eb17401c98ae3a631
Source dataset
uspto-grants-2009_03
Patent number
US07507841B2

Reaction notes

Loading…