3-(2-Methoxyethyl)-2,3,4,5-tetrahydro-1h-3-benzazepin-7-amine → 2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]-pyrimidin-4-ylamino}-N-methyl-N-prop-2-ynyl-benzamide

HRID 178731Notes

Reaction equation

HRID 178731 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][c:8]2[c:9]([cH:12][c:13]([NH2:16])[cH:14][cH:15]2)[CH2:10][CH2:11]1.[Cl:17][c:18]1[n:19][cH:20][c:21]([Cl:38])[c:22]([NH:24][c:25]2[c:26]([C:27](=[O:28])[N:29]([CH2:30][C:31]#[CH:32])[CH3:33])[cH:34][cH:35][cH:36][cH:37]2)[n:23]1>>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][c:8]2[c:9]([cH:12][c:13]([NH:16][c:18]3[n:19][cH:20][c:21]([Cl:38])[c:22]([NH:24][c:25]4[c:26]([C:27](=[O:28])[N:29]([CH2:30][C:31]#[CH:32])[CH3:33])[cH:34][cH:35][cH:36][cH:37]4)[n:23]3)[cH:14][cH:15]2)[CH2:10][CH2:11]1

Participants

3

Reactant 2

HCID 574160893-(2-Methoxyethyl)-2,3,4,5-tetrahydro-1h-3-benzazepin-7-amineHCID 866340272-(2,5-dichloro-pyrimidin-4-ylamino)-N-methyl-N-prop-2-ynyl-benzamide

Product 1

HCID 866340282-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]-pyrimidin-4-ylamino}-N-methyl-N-prop-2-ynyl-benzamide

Sources & evidence

ORD record
ord-4b4296c10848423a94e4f7b1768caaba
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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