THF diisopropyl ether → N-(3-(4-(Hydroxymethyl)phenyl)-2,2,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)-3,3-dimethylbutanamide

HRID 1787367Notes

Reaction equation

HRID 1787367 reaction equation
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[C:13]3[CH:14]=[C:15]([NH:20][C:21](=[O:27])[CH2:22][C:23]([CH3:26])([CH3:25])[CH3:24])[C:16]([CH3:19])=[C:17]([CH3:18])[C:12]=3[O:11][C:10]2([CH3:29])[CH3:28])=[CH:5][CH:4]=1)=[O:2].C1COCC1.C(OC(C)C)(C)C>>[OH:2][CH2:1][C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[C:13]3[CH:14]=[C:15]([NH:20][C:21](=[O:27])[CH2:22][C:23]([CH3:25])([CH3:24])[CH3:26])[C:16]([CH3:19])=[C:17]([CH3:18])[C:12]=3[O:11][C:10]2([CH3:29])[CH3:28])=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 21940044THF diisopropyl etherHCID 23114121N-(3-(4-Formylphenyl)-2,2,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)-3,3-dimethylbutanamide

Product 1

HCID 23114400N-(3-(4-(Hydroxymethyl)phenyl)-2,2,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)-3,3-dimethylbutanamideYield 80%

Procedure

Using N-(3-(4-formylphenyl)-2,2,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)-3,3-dimethylbutanamide obtained in Example 292, the title compound was synthesized in the same manner as in Example 21. Yield: 80%. Melting point: 162-163° C. (THF-diisopropyl ether).

Sources & evidence

ORD record
ord-187d7351c9af48449b1a4c2b8b8231d6
Source dataset
uspto-grants-2009_03
Patent number
US07507841B2

Reaction notes

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