HCID 68711355, compound → HCID 68709946, compound

HRID 1787387Notes

Reaction equation

HRID 1787387 reaction equation
C([NH:8][C:9]1[C:10]([CH3:30])=[C:11]([CH3:29])[C:12]2[O:16][C@@H:15]([CH3:17])[C@@H:14]([C:18]3[CH:23]=[CH:22][C:21]([CH:24]([CH3:26])[CH3:25])=[CH:20][CH:19]=3)[C:13]=2[C:27]=1[CH3:28])C1C=CC=CC=1>CCCCCC>[CH:24]([C:21]1[CH:22]=[CH:23][C:18]([C@H:14]2[C:13]3[C:27]([CH3:28])=[C:9]([NH2:8])[C:10]([CH3:30])=[C:11]([CH3:29])[C:12]=3[O:16][C@H:15]2[CH3:17])=[CH:19][CH:20]=1)([CH3:26])[CH3:25]

Participants

3

Reactant 1

HCID 68711355HCID 68711355, compound

Product 1

HCID 68709946HCID 68709946, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

Using (cis)-3-(4-isopropylphenyl)-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran obtained in Reference Example 352, (cis)-5-bromo-3-(4-isopropylphenyl)-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran was synthesized in the same manner as in Reference Example 23. Using the compound, (cis)-N-benzyl-3-(4-isopropylphenyl)-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-amine was synthesized in the same manner as in Reference Example 24. Using the compound, the title compound was synthesized in the same manner as in Reference Example 30. Yield: 83%. Melting point: 91-92° C. (hexane).

Workup

  1. customwas synthesized in the same manner as in Reference Example 23
  2. customwas synthesized in the same manner as in Reference Example 24

Sources & evidence

ORD record
ord-4d350f32048f4cc39455ea1396d729e5
Source dataset
uspto-grants-2009_03
Patent number
US07507841B2

Reaction notes

Loading…