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HRID1787425

反应详情

EQUATION

反应方程式

HRID 1787425 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)NS(=O)(=O)c1cccc(B(O)O)c1
HCID44119538

[3-(tert-Butylsulfamoyl)phenyl]boronic acid

C10H16BNO4S

结构：Cc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(Br)c1)=N2
HCID67361460

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc2c(cc1C(F)(F)F)NC(=O)CC(c1cccc(-c3cccc(S(=O)(=O)NC(C)(C)C)c3)c1)=N2
HCID25050016

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 4-(3-bromo-phenyl)-7-methyl-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one (Example B.1) (200 mg, 0.50 mmol) and commercially available 3-tert-butylsulfamoyl-benzeneboronic acid [CAS-no. 221290-14-8] (155 mg, 0.60 mmol) according to the general procedure II. Obtained as a light yellow solid (275 mg, 97%). MS (ISP) 530.1 [(M+H)+]; mp 133° C. (dec).