HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3'-(4-Oxo-7-trifluoromethyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-biphenyl-4-sulfonic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 3'-(4-Oxo-7-trifluoromethyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-biphenyl-4-sulfonic acid tert-butylamide | HCID 25052324 | — |
| Product | 3'-(4-Oxo-7-trifluoromethyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-biphenyl-4-sulfonic acid amide | HCID 25052161 | — |
Reaction Steps
The title compound was prepared from 3′-(4-oxo-7-trifluoromethyl-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-biphenyl-4-sulfonic acid tert-butylamide (Example 5) (235 mg, 0.5 mmol) and TFA (5 mL) according to the general procedure I step 2. Obtained as a yellow solid (122 mg, 58%). MS (ISP) 460.1 [(M+H)+]; mp 195-210° C. (dec).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511033B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-d3620a895c3b46169045aa097af17697 |
| Source note | uspto-grants-2009_03 |