HCID 16748343, compound → 862269-93-0

HRID 1787446Notes

Reaction equation

HRID 1787446 reaction equation
C(O[C:6]([N:8]1[CH2:13][CH2:12][N:11]([C@@H:14]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[CH3:15])[CH2:10][CH2:9]1)=O)(C)(C)C.ClC1[N:29]=[CH:28][N:27]=[C:26]([O:30][C:31]2[C:36]3[N:37]=[C:38]([NH:40][C:41](=[O:43])[CH3:42])[S:39][C:35]=3[CH:34]=[CH:33][CH:32]=2)[CH:25]=1>>[F:22][C:19]1[CH:18]=[CH:17][C:16]([C@H:14]([N:11]2[CH2:10][CH2:9][N:8]([C:6]3[N:29]=[CH:28][N:27]=[C:26]([O:30][C:31]4[C:36]5[N:37]=[C:38]([NH:40][C:41](=[O:43])[CH3:42])[S:39][C:35]=5[CH:34]=[CH:33][CH:32]=4)[CH:25]=3)[CH2:13][CH2:12]2)[CH3:15])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 16748343HCID 16748343, compoundHCID 167487991,1-Dimethylethyl 4-[(1R)-1-(4-fluorophenyl)ethyl]-1-piperazinecarboxylate

Product 1

HCID 11352366862269-93-0

Procedure

According to the procedures described in Example 21(b), 4-[(1R)-1-(4-fluoro-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester, Example 21(a), (0.48 g, 1.6 mmol) and N-[4-(6-chloro-pyrimidin-4-yloxy)-benzothiazol-2-yl]-acetamide, Example 1(b), (0.512 g, 1.6 mmol) provided the title compound as a white solid. M.p.: 243.8-245.9° C. MS (ESI, pos. ion.) m/z: 493 (M+1).

Sources & evidence

ORD record
ord-9cecf2ea9b4d4387b2f625c003d5cae9
Source dataset
uspto-grants-2009_03
Patent number
US07511044B2

Reaction notes

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