HCID 11213370, compound → HCID 11431551, compound

HRID 1787447Notes

Reaction equation

HRID 1787447 reaction equation
[NH2:1][C:2]1[C:3](=[O:21])[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([O:12][C:13]1[CH:18]=[C:17](Cl)[N:16]=[CH:15][N:14]=1)[CH:8]=[C:7]([F:20])[CH:6]=2.NC1C(=O)NC2C(N=1)=C(OC1C=C([N:40]3[CH2:45][CH2:44][N:43]([C@H:46]([C:48]4[CH:53]=[CH:52][C:51]([F:54])=[CH:50][CH:49]=4)[CH3:47])[CH2:42][CH2:41]3)N=CN=1)C=CC=2>>[NH2:1][C:2]1[C:3](=[O:21])[NH:4][C:5]2[C:10]([N:11]=1)=[C:9]([O:12][C:13]1[CH:18]=[C:17]([N:40]3[CH2:41][CH2:42][N:43]([C@H:46]([C:48]4[CH:53]=[CH:52][C:51]([F:54])=[CH:50][CH:49]=4)[CH3:47])[CH2:44][CH2:45]3)[N:16]=[CH:15][N:14]=1)[CH:8]=[C:7]([F:20])[CH:6]=2

Participants

3

Reactant 2

HCID 11213370HCID 11213370, compoundHCID 57600074HCID 57600074, compound

Product 1

HCID 11431551HCID 11431551, compound

Procedure

3-Amino-5-(6-chloropyrimidin-4-yloxy)-7-fluoroquinoxalin-2(1H)-one, Example 57(h), (150 mg, 0.49 mmol) was reacted with (S)-1-(1-(4-fluorophenyl)ethyl)piperazine (101 mg, 0.49 mmol, prepared as described in Example 27) under the conditions of Example 26(b) to give the title compound. MS (ESI, pos. ion.) m/z: 480 (M+1). Mp: 288° C.

Sources & evidence

ORD record
ord-a0585b807a8e4b67a224dd02c7df4d41
Source dataset
uspto-grants-2009_03
Patent number
US07511044B2

Reaction notes

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