HCID 11213370, compound → HCID 11408902, compound

HRID 1787448Notes

Reaction equation

HRID 1787448 reaction equation
[NH2:1][C:2]1[C:3](=[O:21])[N:4]([CH3:20])[C:5]2[C:10]([N:11]=1)=[C:9]([O:12][C:13]1[CH:18]=[C:17](Cl)[N:16]=[CH:15][N:14]=1)[CH:8]=[CH:7][CH:6]=2.NC1C(=O)NC2C(N=1)=C(OC1C=C([N:40]3[CH2:45][CH2:44][N:43]([C@H:46]([C:48]4[CH:53]=[CH:52][C:51]([F:54])=[CH:50][CH:49]=4)[CH3:47])[CH2:42][CH2:41]3)N=CN=1)C=CC=2>>[NH2:1][C:2]1[C:3](=[O:21])[N:4]([CH3:20])[C:5]2[C:10]([N:11]=1)=[C:9]([O:12][C:13]1[CH:18]=[C:17]([N:40]3[CH2:41][CH2:42][N:43]([C@H:46]([C:48]4[CH:53]=[CH:52][C:51]([F:54])=[CH:50][CH:49]=4)[CH3:47])[CH2:44][CH2:45]3)[N:16]=[CH:15][N:14]=1)[CH:8]=[CH:7][CH:6]=2

Participants

3

Reactant 2

HCID 11213370HCID 11213370, compoundHCID 57600068HCID 57600068, compound

Product 1

HCID 11408902HCID 11408902, compound

Procedure

3-Amino-5-(6-chloropyrimidin-4-yloxy)-1-methylquinoxalin-2(1H)-one, Example 59(e), (80 mg, 0.26 mmol) was reacted with (S)-1-(1-(4-fluorophenyl)ethyl)piperazine (55 mg, 0.26 mmol, prepared as described in Example 27) under the conditions of Example 26(b) to give the title compound. MS (ESI, pos. ion.) m/z: 476 (M+1).

Sources & evidence

ORD record
ord-b0f5db73cb5045589fd05763220d22dd
Source dataset
uspto-grants-2009_03
Patent number
US07511044B2

Reaction notes

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