Acetic Anhydride → HCID 57600034, compound

HRID 1787449Notes

Reaction equation

HRID 1787449 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[N:21]=[CH:20][N:19]=[C:18]([O:22][C:23]4[C:28]5[N:29]=[C:30]([NH2:32])[O:31][C:27]=5[CH:26]=[CH:25][CH:24]=4)[CH:17]=3)[CH2:12][CH2:11]2)[CH3:9])=[CH:4][CH:3]=1.[C:33](OC(=O)C)(=[O:35])[CH3:34]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[N:21]=[CH:20][N:19]=[C:18]([O:22][C:23]4[C:28]5[N:29]=[C:30]([NH:32][C:33](=[O:35])[CH3:34])[O:31][C:27]=5[CH:26]=[CH:25][CH:24]=4)[CH:17]=3)[CH2:12][CH2:11]2)[CH3:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 57600086HCID 57600086, compound

Product 1

HCID 57600034HCID 57600034, compound

Procedure

4-(6-(4-(1-(4-Fluorophenyl)ethyl)piperazin-1-yl)pyrimidin-4-yloxy)benzo[d]oxazol-2-amine (0.06 g, 0.14 mmol, Example 63) was reacted with acetic anhydride under the conditions of Example 1(b) to give the desired product. Mp: 199.8° C. MS (ESI, pos. ion) m/z: 477 (M+1).

Sources & evidence

ORD record
ord-08ac0f7c53764af08ba7cbf2fe59ffb9
Source dataset
uspto-grants-2009_03
Patent number
US07511044B2

Reaction notes

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