Sodium periodate → HCID 58980662, compound

Participants

Reaction Conditions

Reaction Steps

Sodium periodate (1.23 g, 5.76 mmol) in water (2.0 mL) was added to a solution of the above thioether (1.08 g, 4.80 mmol) in MeOH/THF (2:1, 15 mL). The mixture was stirred at 50° C. for 24 h, and then concentrated. The residue was diluted with Et2O and washed with water and saturated NaHCO3, dried over Na2SO4, filtered, and concentrated. Purification by silica-gel chromatography (0-50% EtOAc in CH2Cl2) provided 4-tert-butyl-1-methanesulfinyl-2-nitro-benzene (1.05 g, 91%) as a white solid.

Provenance & Evidence