Benzimidazole → HCID 10361912, compound

HRID 1787472Notes

Reaction equation

HRID 1787472 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[CH:11][CH:10]=2)[CH:5]=[N:4][CH:3]=1.[N:21]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[NH:23][CH:22]=1>>[N:21]1([C:2]2[N:7]=[C:6]([NH:8][C:9]3[CH:14]=[CH:13][C:12]([N:15]4[CH2:20][CH2:19][O:18][CH2:17][CH2:16]4)=[CH:11][CH:10]=3)[CH:5]=[N:4][CH:3]=2)[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[N:23]=[CH:22]1

Participants

3

Reactant 2

HCID 5798BenzimidazoleHCID 58934272HCID 58934272, compound

Product 1

HCID 10361912HCID 10361912, compoundYield 31%

Procedure

In a procedure analogous to example 12, reaction of 6-chloro-N-(4-morpholin-4-ylphenyl)pyrazin-2-amine (150 mg, 0.52 mmol) and benzimidazole (67 mg, 0.57 mmol) furnished the product (60 mg, 31%).

Sources & evidence

ORD record
ord-4c7cb8211018456f990a8282585bd4ac
Source dataset
uspto-grants-2009_03
Patent number
US07511047B2

Reaction notes

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