2-Methylbenzimidazole → 6-(2-Methyl-1H-benzimidazol-1-yl)-N-[(1S)-1-phenylethyl]pyrazin-2-amine

HRID 1787474Notes

Reaction equation

HRID 1787474 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C@H:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH3:10])[CH:5]=[N:4][CH:3]=1.[CH3:17][C:18]1[NH:19][C:20]2[CH:26]=[CH:25][CH:24]=[CH:23][C:21]=2[N:22]=1>>[CH3:17][C:18]1[N:22]([C:2]2[N:7]=[C:6]([NH:8][C@H:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH3:10])[CH:5]=[N:4][CH:3]=2)[C:21]2[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=2[N:19]=1

Participants

3

Reactant 2

HCID 119842-MethylbenzimidazoleHCID 587170806-Chloro-N-[(1S)-1-phenylethyl]pyrazin-2-amine

Product 1

HCID 103366906-(2-Methyl-1H-benzimidazol-1-yl)-N-[(1S)-1-phenylethyl]pyrazin-2-amineYield 11%

Procedure

In a procedure analogous to example 12, reaction of 6-chloro-N-[(1S)-1-phenylethyl]pyrazin-2-amine (120 mg, 0.51 mmol) and 2-methyl-benzimidazole (75 mg, 0.57 mmol) furnished the product (18 mg, 11%).

Sources & evidence

ORD record
ord-bdc11013ee6041548616072ab4ad7d66
Source dataset
uspto-grants-2009_03
Patent number
US07511047B2

Reaction notes

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