HCID 43389031, compound → 1-[6-{[(1S)-1-phenylethyl]amino}pyrazin-2-yl]-N-(2-hydroxyethyl)-1H-benzimidazole-5-carboxamide

HRID 1787475Notes

Reaction equation

HRID 1787475 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C@H:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH3:10])[CH:5]=[N:4][CH:3]=1.[OH:17][CH2:18][CH2:19][NH:20][C:21]([C:23]1[CH:31]=[CH:30][C:26]2[N:27]=[CH:28][NH:29][C:25]=2[CH:24]=1)=[O:22]>>[C:11]1([C@@H:9]([NH:8][C:6]2[N:7]=[C:2]([N:27]3[C:26]4[CH:30]=[CH:31][C:23]([C:21]([NH:20][CH2:19][CH2:18][OH:17])=[O:22])=[CH:24][C:25]=4[N:29]=[CH:28]3)[CH:3]=[N:4][CH:5]=2)[CH3:10])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 43389031HCID 43389031, compoundHCID 587170806-Chloro-N-[(1S)-1-phenylethyl]pyrazin-2-amine

Product 1

HCID 98012331-[6-{[(1S)-1-phenylethyl]amino}pyrazin-2-yl]-N-(2-hydroxyethyl)-1H-benzimidazole-5-carboxamide

Procedure

In a procedure analogous to example 12, reaction of 6-chloro-N-[(1S)-1-phenylethyl]pyrazin-2-amine (91 mg, 0.39 mmol) and benzimidazole 5-carboxylic acid (2-hydroxyethyl)amide (88 mg, 0.43 mmol) furnished the product which was purified by column chromatography (22 mg, 14%).

Workup

  1. customfurnished the product which
  2. customwas purified by column chromatography (22 mg, 14%)

Sources & evidence

ORD record
ord-9ba5e3d5979143419183d687423643e9
Source dataset
uspto-grants-2009_03
Patent number
US07511047B2

Reaction notes

Loading…