Water → HCID 10002649, compound

Participants

Reaction Steps

A solution of 6-{5-[(4-methylpiperazin-1-yl)carbonyl]-1H-benzimidazol-1-yl}-N-[(1S)-1-phenylethyl]pyrazin-2-amine (22 mg, 0.05 mmol) in dry THF (1 mL) was added to a suspension of LiAlH4 (4 mg, 0.1 mmol) in THF (1 mL) and the mixture heated at reflux for 4 h. Upon cooling to RT, the solution was treated consecutively with H2O (1 mL), aqueous NaOH (1 mL, 2M) and H2O (5 mL). The resulting mixture was extracted with CHCl3 (2×10 mL) and the combined organic layers dried (Na2SO4). The solvent was removed under reduced pressure and the product purified by flash chromatography using CH2Cl2-MeOH (10:1→1:1) as eluant to afford the product as a yellow solid (11 mg, 52%).

Provenance & Evidence