6-ethyl-3-methyl-4-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one → HCID 68487141, compound

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Reaction Steps

A mixture of 6-ethyl-3-methyl-4-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one (Dal Piaz, V et al., J. Med. Chem. 1997, 40, 1417) (2.0 g, 7.83 mmol) and 10% palladium on charcoal (400 mg) in ethanol (400 mL) was shaken under hydrogen at room temperature and 2 bar for 3 h. The catalyst was filtered off and the solvent was removed under reduced pressure to yield the title compound (98% yield).

Provenance & Evidence