Methanol → HCID 11153311, compound

HRID 1787505Notes

Reaction equation

HRID 1787505 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:10](=[O:26])[N:11]([CH2:24][CH3:25])[N:12]=[C:13]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:14]=2[CH:15]([OH:17])[CH3:16])[CH:5]=[CH:6][CH:7]=1.[CH3:27]O>O>[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:10](=[O:26])[N:11]([CH2:24][CH3:25])[N:12]=[C:13]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:14]=2[CH:15]([O:17][CH3:27])[CH3:16])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 11485504HCID 11485504, compound

Product 1

HCID 11153311HCID 11153311, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
120 °C

Procedure

To a solution of the title product of example 1 (111 mg, 0.3 mmol mmol) in methanol (5 mL), PPA (600 mg) was added and the mixture was stirred in a sealed tube at 120° C. for 10 h. Then it was let to cool down and was diluted with water. The final product was isolated by filtration (96% yield).

Workup

  1. temperatureto cool down

Sources & evidence

ORD record
ord-9e603ac250a242c08cc7b9a7d7e16415
Source dataset
uspto-grants-2009_03
Patent number
US07511038B2

Reaction notes

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