HCID 11485504, compound → HCID 11416854, compound

Participants

Reaction Steps

To a solution of the title compound of example 1 (185 mg, 0.5 mmol) in toluene (8 mL), H2SO4 adsorbed on silica gel (Chavetz et al., Synthetic Communications, 24, 2325, 1884) (400 mg) was added portionwise during 4 h at 80° C. Then silica gel was filtered off and the residue was thoroughly washed with acetone. Solvent was removed under reduced pressure and the residue was treated with ice water. The final product precipitated and was isolated by filtration (63% yield).

Provenance & Evidence