HCID 11416854, compound → HCID 11450008, compound

HRID 1787507Notes

Reaction equation

HRID 1787507 reaction equation
Cl[C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:10](=[O:25])[N:11]([CH2:23][CH3:24])[N:12]=[C:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:14]=2[CH:15]=[CH2:16])[CH:5]=[CH:6][CH:7]=1>[Pd].C(O)C>[NH:8]([C:9]1[C:10](=[O:25])[N:11]([CH2:23][CH3:24])[N:12]=[C:13]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:14]=1[CH2:15][CH3:16])[C:4]1[CH:3]=[CH:2][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 11416854HCID 11416854, compound

Product 1

HCID 11450008HCID 11450008, compoundYield 71%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of the title compound of example 3 (67 mg, 0.19 mmol) and 10% palladium on charcoal (50 mg) in ethanol (10 mL) was shaken under hydrogen at room temperature and 4 bar for 2 h. The catalyst was filtered off and the solvent was removed under reduced pressure to yield the title compound (71% yield).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-5475dbcdc42941618b8c29d570db44e3
Source dataset
uspto-grants-2009_03
Patent number
US07511038B2

Reaction notes

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