反应详情

Place 1-aminopyrrolidin-2-one hydrochloride (Zubek, A. Z. Chem., 1969, 9(2), 58; 155.6 g, 1.14 mol) in a 3 L flask equipped with mechanical stirrer and nitrogen inlet. Add 3-oxo-3-pyridin-2-yl-propionic acid ethyl ester (Preparation 2, Part A; 200 g, 1.04 mol) and pyridine (400 mL). Stir the reaction mixture at room temperature for 20 h. Dilute the mixture with water (500 mL) and extract with toluene (2×500 mL). Combine the organic layers, dry (sodium sulfate), filter, and concentrate in vacuo to yield 280 g (98%) of the subtitled compound as a dark oil. MS (ES) m/z=276 (M+H).

1. custom155.6 g, 1.14 mol) in a 3 L flask equipped with mechanical stirrer and nitrogen inlet
2. extractionextract with toluene (2×500 mL)
3. dry with materialCombine the organic layers, dry (sodium sulfate)
4. filtrationfilter
5. concentrationconcentrate in vacuo