3-Pyridinylboronic acid → HCID 16118957, compound

HRID 1787612Notes

Reaction equation

HRID 1787612 reaction equation
Br[C:2]1[CH:11]=[N:10][C:9](Cl)=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.[N:13]1[CH:18]=[C:17](B(O)O)[CH:16]=[CH:15][CH:14]=1.[NH2:22][C:23]1[N:24]=[C:25]([CH3:28])[S:26][CH:27]=1>>[CH3:28][C:25]1[S:26][CH:27]=[C:23]([NH:22][C:9]2[N:10]=[CH:11][C:2]([C:15]3[CH:14]=[N:13][CH:18]=[CH:17][CH:16]=3)=[C:3]3[C:8]=2[N:7]=[CH:6][CH:5]=[CH:4]3)[N:24]=1

Participants

4

Reactant 3

HCID 27343783-Pyridinylboronic acidHCID 147727002-Methyl-1,3-thiazol-4-amineHCID 422813655-Bromo-8-chloro-1,7-naphthyridine

Product 1

HCID 16118957HCID 16118957, compound

Procedure

The title compound, MS: m/e=320.2 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 5-bromo-8-chloro-[1,7]naphthyridine (Example H), 5-pyridineboronic acid and 4-amino-2-methylthiazole (Example F).

Sources & evidence

ORD record
ord-fd6575b9037a45eeb030e76a9944b47f
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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