3-Pyridinylboronic acid → (5-Fluoro-pyridin-2-yl)-(2-methyl-5-pyridin-3-yl-[1,7]naphthyridin-8-yl)-amine

HRID 1787615Notes

Reaction equation

HRID 1787615 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5](I)=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[N:14]1[CH:19]=[CH:18][CH:17]=[C:16](B(O)O)[CH:15]=1.[NH2:23][C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][N:25]=1>>[F:30][C:27]1[CH:28]=[CH:29][C:24]([NH:23][C:2]2[N:3]=[CH:4][C:5]([C:16]3[CH:15]=[N:14][CH:19]=[CH:18][CH:17]=3)=[C:6]3[C:11]=2[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]3)=[N:25][CH:26]=1

Participants

4

Reactant 3

HCID 27343783-Pyridinylboronic acidHCID 27377012-Amino-5-fluoropyridineHCID 576003528-Chloro-5-iodo-2-methyl-[1,7]naphthyridine

Product 1

HCID 16118960(5-Fluoro-pyridin-2-yl)-(2-methyl-5-pyridin-3-yl-[1,7]naphthyridin-8-yl)-amine

Procedure

The title compound, MS: m/e=332.2 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-5-iodo-2-methyl-[1,7]naphthyridine (Example I), 3-pyridineboronic acid and 2-amino-5-fluoropyridine.

Sources & evidence

ORD record
ord-3b92ed255f6441148c52dd03745aac81
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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