HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloropyridine-5-boronic acid → [5-(6-Chloro-pyridin-3-yl)-2-methyl-[1,7]naphthyridin-8-yl]-(2-methyl-thiazol-4-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloropyridine-5-boronic acid | HCID 3845034 | — |
| Reactant | 2-Methyl-1,3-thiazol-4-amine | HCID 14772700 | — |
| Reactant | 8-Chloro-5-iodo-2-methyl-[1,7]naphthyridine | HCID 57600352 | — |
| Product | [5-(6-Chloro-pyridin-3-yl)-2-methyl-[1,7]naphthyridin-8-yl]-(2-methyl-thiazol-4-yl)-amine | HCID 16116926 | — |
Reaction Steps
The title compound, MS: m/e=368.0 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-5-iodo-2-methyl-[1,7]naphthyridine (Example I), 2-chloro-5-pyridineboronic acid and 4-amino-2-methylthiazole (Example F).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511055B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-49090720f4af4bad98f01904fd8727ca |
| Source note | uspto-grants-2009_03 |