(Pyrimidin-5-yl)boronic acid → HCID 16117057, compound

HRID 1787635Notes

Reaction equation

HRID 1787635 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5](I)=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[N:14]1[CH:19]=[C:18](B(O)O)[CH:17]=[N:16][CH:15]=1.[NH2:23][C:24]1[S:25][CH:26]=[C:27]([Cl:29])[N:28]=1>>[Cl:29][C:27]1[N:28]=[C:24]([NH:23][C:2]2[N:3]=[CH:4][C:5]([C:18]3[CH:19]=[N:14][CH:15]=[N:16][CH:17]=3)=[C:6]3[C:11]=2[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]3)[S:25][CH:26]=1

Participants

4

Reactant 3

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 98339722-Amino-4-chlorothiazoleHCID 576003528-Chloro-5-iodo-2-methyl-[1,7]naphthyridine

Product 1

HCID 16117057HCID 16117057, compound

Procedure

The title compound, MS: m/e=354.9 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-5-iodo-2-methyl-[1,7]naphthyridine (Example I), 5-pyrimidineboronic acid and 2-amino-4-chlorothiazole (Example K).

Sources & evidence

ORD record
ord-23e706a96f3a4716881141931693c60c
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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