1-Methyl-3-aminopyrazole → HCID 16117453, compound

HRID 1787644Notes

Reaction equation

HRID 1787644 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5](I)=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[F:14][C:15]1[CH:16]=[C:17](B(O)O)[CH:18]=[CH:19][CH:20]=1.[CH3:24][N:25]1[CH:29]=[CH:28][C:27]([NH2:30])=[N:26]1>>[F:14][C:15]1[CH:16]=[C:17]([C:5]2[CH:4]=[N:3][C:2]([NH:30][C:27]3[CH:28]=[CH:29][N:25]([CH3:24])[N:26]=3)=[C:11]3[C:6]=2[CH:7]=[CH:8][C:9]([CH3:12])=[N:10]3)[CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 27339863-Fluorophenylboronic acidHCID 576003528-Chloro-5-iodo-2-methyl-[1,7]naphthyridine

Product 1

HCID 16117453HCID 16117453, compound

Procedure

The title compound, MS: m/e=334.2 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-5-iodo-2-methyl-[1,7]naphthyridine (Example I), 3-fluorophenylboronic acid and 1-methyl-1H-pyrazol-3-ylamine.

Sources & evidence

ORD record
ord-1c7fd9a87d9841b3ad10e4426fe85aca
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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