5-Bromo-3-methyl-1,2,4-thiadiazole → HCID 16117315, compound

HRID 1787650Notes

Reaction equation

HRID 1787650 reaction equation
Cl[C:2]1[C:11]2[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7][C:6]=2[C:5](B(O)O)=[CH:4][N:3]=1.Br[C:17]1[S:21][N:20]=[C:19]([CH3:22])[N:18]=1.[NH2:23][C:24]1[N:25]=[C:26]([CH3:29])[S:27][CH:28]=1>>[CH3:12][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[C:2]([NH:23][C:24]3[N:25]=[C:26]([CH3:29])[S:27][CH:28]=3)[N:3]=[CH:4][C:5]=2[C:17]2[S:21][N:20]=[C:19]([CH3:22])[N:18]=2)[N:10]=1

Participants

4

Reactant 3

HCID 129191605-Bromo-3-methyl-1,2,4-thiadiazoleHCID 147727002-Methyl-1,3-thiazol-4-amineHCID 57416446(8-Chloro-2-methyl-1,7-naphthyridin-5-yl)boronic acid

Product 1

HCID 16117315HCID 16117315, compound

Procedure

The title compound, MS: m/e=355.2 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-2-methyl-[1,7]naphthyridine-5-boronic acid (Example L), 5-bromo-3-methyl-[1,2,4]thiadiazole (Example M) and 4-amino-2-methylthiazole (Example F).

Sources & evidence

ORD record
ord-1f39228ea28d434db4d6faf5140b443b
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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