5-Bromo-2-methylpyrimidine → HCID 16117316, compound

HRID 1787651Notes

Reaction equation

HRID 1787651 reaction equation
Cl[C:2]1[C:11]2[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7][C:6]=2[C:5](B(O)O)=[CH:4][N:3]=1.Br[C:17]1[CH:18]=[N:19][C:20]([CH3:23])=[N:21][CH:22]=1.[NH2:24][C:25]1[N:26]=[C:27]([CH3:30])[S:28][CH:29]=1>>[CH3:12][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[C:2]([NH:24][C:25]3[N:26]=[C:27]([CH3:30])[S:28][CH:29]=3)[N:3]=[CH:4][C:5]=2[C:17]2[CH:18]=[N:19][C:20]([CH3:23])=[N:21][CH:22]=2)[N:10]=1

Participants

4

Reactant 3

HCID 143877445-Bromo-2-methylpyrimidineHCID 147727002-Methyl-1,3-thiazol-4-amineHCID 57416446(8-Chloro-2-methyl-1,7-naphthyridin-5-yl)boronic acid

Product 1

HCID 16117316HCID 16117316, compound

Procedure

The title compound, MS: m/e=349.2 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-2-methyl-[1,7]naphthyridine-5-boronic acid (Example L), 5-bromo-2-methylpyrimidine and 4-amino-2-methylthiazole (Example F).

Sources & evidence

ORD record
ord-93418a0b20b74152a9703a735a9b061b
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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