2-Thiazolamine, 4-(trifluoromethyl)- → HCID 16117319, compound

HRID 1787654Notes

Reaction equation

HRID 1787654 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5](I)=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[N:14]1[CH:19]=[CH:18][CH:17]=[C:16](B(O)O)[CH:15]=1.[NH2:23][C:24]1[S:25][CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[N:28]=1>>[CH3:12][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[C:2]([NH:23][C:24]3[S:25][CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[N:28]=3)[N:3]=[CH:4][C:5]=2[C:16]2[CH:15]=[N:14][CH:19]=[CH:18][CH:17]=2)[N:10]=1

Participants

4

Reactant 3

HCID 12014172-Thiazolamine, 4-(trifluoromethyl)-HCID 27343783-Pyridinylboronic acidHCID 576003528-Chloro-5-iodo-2-methyl-[1,7]naphthyridine

Product 1

HCID 16117319HCID 16117319, compound

Procedure

The title compound, MS: m/e=388.2 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-5-iodo-2-methyl-[1,7]naphthyridine (Example I), 3-pyridineboronic acid and 2-amino-4-(trifluoromethyl)thiazole.

Sources & evidence

ORD record
ord-20ce52d0317e489b94bbf3070c4941a5
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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