Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 5-(Benzyloxy)-2-(hydroxymethyl)-1,4-dihydropyridin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Kojic Acid | HCID 3840 | — |
| 반응물 | 5-(benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one | HCID 901598 | — |
| 반응물 | Guaiacylglycerol-beta-guaiacyl ether | HCID 6424189 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 5-(Benzyloxy)-2-(hydroxymethyl)-1,4-dihydropyridin-4-one | HCID 2801564 | — |
반응 단계
A mixture of 5-benzyloxy-2-hydroxymethyl-4-pyrone (prepared from Kojic acid by the method of D. Erol, J. Med. Chem., 1994, 29, 893) (9.7 g, 40 mmol), concentrated aqueous (880) ammonia (100 mL), and ethanol (20 mL) was heated to reflux overnight. The mixture was allowed to cool to room temperature then filtered. The resultant solid was washed with ether and dried in vacuo (5.9 g); MS (APCI+) m/z 232 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07511035B2 |
| 출처 데이터셋 | uspto-grants-2009_03 |
| ORD ID | ord-877c28ca71f04fb4b49300ed1d05bc24 |
| 출처 메모 | uspto-grants-2009_03 |