HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrobenzoic Acid → HCID 17615467, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrobenzoic Acid | HCID 6108 | — |
| Reactant | 1-Pyrrolidinepropanamine | HCID 31670 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 17615467 | HCID 17615467 | 67.9% |
Reaction Steps
500 mg of 4-nitrobenzoic acid is dissolved in 20 ml of dimethylformamide, mixed with 370 μl of triethylamine, 342 mg of N-(3-aminopropyl)-pyrrolidine and 866 mg TBTU, and stirred for 20 hours at room temperature. The reaction mixture is mixed with semi-saturated sodium bicarbonate solution and extracted with dichloromethane. The organic solution is washed with saturated sodium chloride solution, dried on sodium sulfate, concentrated by evaporation, and after purification by chromatography on silica gel, 502 mg of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511059B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-a93efac43ae64714959bf862a476e87d |
| Source note | uspto-grants-2009_03 |