Methyl 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoate → 5-Phenyl-1,3,4-oxadiazole-2-propionic acid

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Reaction Steps

A mixture of methyl 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoate (600 mg, 2.0 mmol) in 1 M of aqueous NaOH (10 mL) and Methanol (10 mL) was stirred at room temperature overnight. The reaction solution was adjusted to pH 5 and extracted with ethyl acetate three times. The combined organic layers were dried, filtered and concentrated to yield the desired product (0.50 g, 83%). LCMS calculated for C11H11N2O3(M+H): 219.1; found 219.1.

Provenance & Evidence