反应详情

The mixture of N′-[(2E)-6-oxo-3-pentyl-1,3,6,7-tetrahydro-2H-purin-2-ylidene]-4-(3-phenyl-1,2,4-oxadiazol-5-yl)butanohydrazide (2.78 g, 6.17 mmol) in toluene (100 ml) was refluxed for 2 hours. After cooling to room temperature, the solid was filtered, washed with ethyl acetate/Hexane (1:9) and dried to give the desired product (1.97 g, 74% yield). LCMS calculated for C22H25N8O2 (M+H): 433.2; found: 433.1.

1. temperaturewas refluxed for 2 hours
2. filtrationthe solid was filtered
3. washwashed with ethyl acetate/Hexane (1:9)
4. customdried