N-bromobutanimide → HCID 57600276, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 3-(2-aminoethyl)-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one (310 mg, 1.1 mmol) in THF (50 mL), was added N-Bromosuccinimide (0.29 g, 1.6 mmol). The mixture was stirred at 70° C. for 1 hour. The reaction mixture was concentrated. The solid was filtered and washed with EtOAc to yield the desired product (300 mg, 76% yield). LCMS calculated for C13H19BrN7O (M+H): 368.1, 370.1; found: 368.0, 370.0.

Provenance & Evidence