Sodium borohydride → HCID 68877648, compound

Participants

Reaction Steps

13 g of methyl 2-benzyloxy-5-(1-hydroxy-2-{3-[3-(4-methoxy-phenyl)-imidazol-1-yl]-1,1-dimethyl-propylamino}-ethyl)-benzoate in 100 mL tetrahydrofuran are reacted with a solution of 6.5 g of calcium chloride in 65 mL ethanol and 4.5 g of sodium borohydride analogously to the method used for Example 1c. After a reaction time of 12 hours, 3 g of calcium chloride, dissolved in 30 mL ethanol, and 2 g of sodium borohydride are added and stirring is continued for a further 12 hours. Then the mixture is worked up as described, except that extraction is carried out using chloroform rather than ethyl acetate. During the evaporation of this organic phase a solid is precipitated out. The solid is suction filtered, stirred with ethyl acetate and recrystallised from acetonitrile. Yield: 79.5 g (77%); m.p.=108-111° C.

Provenance & Evidence