HCID 68879849, compound → HCID 57602519, compound

Participants

Reaction Steps

3.8 g of 1-(4-benzyloxy-3-hydroxymethyl-phenyl)-2-{3-[3-(4-methoxy-phenyl)-[1,2,4]triazol-1-yl]-1,1-dimethyl-propylamino}-ethanol are hydrogenated with 0.6 g of palladium on charcoal (5%) as catalyst in 75 mL methanol and 75 mL tetrahydrofuran. Then the catalyst is suction filtered and the filtrate is evaporated down. The residue is dissolved in 15 mL 15% m acetonitrile, acidified with formic acid and combined with a crystallisation aid. The precipitated product is separated off and washed. Yield: 2.8 g (81%, formate); m.p.=142-145° C.

Provenance & Evidence