HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalic Acid → Methyl 2-benzyloxy-5-[2-[1,1-dimethyl-3-[1,2,4]triazol-1-yl-propylamino]-1-hydroxy-ethyl]-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalic Acid | HCID 971 | — |
| Reactant | 2-methyl-4-(1H-1,2,4-triazol-1-yl)butan-2-amine | HCID 59754199 | — |
| Reactant | Methyl benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-benzoate | HCID 68858509 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Methyl 2-benzyloxy-5-[2-[1,1-dimethyl-3-[1,2,4]triazol-1-yl-propylamino]-1-hydroxy-ethyl]-benzoate | HCID 68877359 | — |
Reaction Steps
9.5 g of methyl 2-benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-benzoate and 3.1 g of 1,1-dimethyl-3-[1,2,4]triazol-1-yl-propylamine are reacted and worked up analogously to the method described for Example 2a. The crude product is dissolved in 100 mL 95% ethanol and combined with an ethanolic solution of 1.8 g of oxalic acid. After the addition of a crystallisation aid the precipitated product is separated off and washed. Yield: 8 g (64%, bisoxalate), m.p.=220-222° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511067B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-e9eb6ee0f02c4baba66eefb6b40f809a |
| Source note | uspto-grants-2009_03 |