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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1787902Generated: October 29, 2026

Methyl 4-fluorosalicylate → Methyl 4-fluoro-2-(3-tert-butoxycarbonylaminopropoxy)benzoate

https://huagongshe.com/reaction/1787902

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 4-fluorosalicylateHCID 2775386—
Reactanttert-butyl N-(3-hydroxypropyl)carbamateHCID 3838134—
SolventDiethyl EtherHCID 3283—
ProductMethyl 4-fluoro-2-(3-tert-butoxycarbonylaminopropoxy)benzoateHCID 57602453—

Reaction Steps

Using a procedure equivalent to Example 1-F, methyl 4-fluoro-2-hydroxybenzoate and 3-(tert-butoxycarbonylamino)-propanol gave the ether product as a white solid (20.6 g, 84%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07511066B2
Source datasetuspto-grants-2009_03
ORD IDord-56a1adc8b61e4717a5028e9720267380
Source noteuspto-grants-2009_03