Trifluoroacetic acid → HCID 57602496, compound

Participants

Reaction Steps

The 3-[2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(tert-butyl)benzoylamino]-N-(5-chloropyridin-2-yl)pyridine-4-carboxamide (60 mg, 0.1 mmol) was mixed with anisole (1 mL) and CH2Cl2 (2 mL) then treated with trifluoroacetic acid (1 mL). The reaction was stirred at ambient temperature for 4 h, concentrated under vacuum to dryness and mixed with CH2Cl2. This was filtered through a 1 g SCX ion exchange column using 2 M NH3 in MeOH. Concentration to dryness gave 32 mg of the title compound as a solid.

Provenance & Evidence