HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(2-Fluoroethoxy)-2-hydroxybenzoate → Methyl 2-(3-tert-butoxycarbonylamino-2,2-dimethylpropoxy)-4-(2-fluoroethoxy)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(2-Fluoroethoxy)-2-hydroxybenzoate | HCID 10420774 | — |
| Reactant | tert-butyl N-(3-hydroxy-2,2-dimethylpropyl)carbamate | HCID 21263232 | — |
| Product | Methyl 2-(3-tert-butoxycarbonylamino-2,2-dimethylpropoxy)-4-(2-fluoroethoxy)benzoate | HCID 86610266 | 72% |
Reaction Steps
Using a procedure similar to that of Example 26-B, methyl 4-(2-fluoroethoxy)-2-hydroxybenzoate (3.6 g, 17.8 mmol) is alkylated with 3-tert-butoxycarbonylamino-2,2-dimethylpropanol (3.62 g, 17.8 mmol) to afford methyl 2-(3-tert-butoxycarbonylamino-2,2-dimethylpropoxy)-4-(2-fluoroethoxy)benzoate (5.12 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511066B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-3391cfa1a6a840eebbbe1fab055a94af |
| Source note | uspto-grants-2009_03 |