Tert-butyl 4-hydroxypiperidine-1-carboxylate → HCID 68835888, compound

HRID 1787937Notes

Reaction equation

HRID 1787937 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]([O:12][CH2:13][C:14]([F:17])([F:16])[F:15])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[C:18]([O:22][C:23]([N:25]1[CH2:30][CH2:29][CH:28](O)[CH2:27][CH2:26]1)=[O:24])([CH3:21])([CH3:20])[CH3:19]>>[C:18]([O:22][C:23]([N:25]1[CH2:30][CH2:29][CH:28]([O:1][C:2]2[CH:11]=[C:10]([O:12][CH2:13][C:14]([F:15])([F:16])[F:17])[CH:9]=[CH:8][C:3]=2[C:4]([O:6][CH3:7])=[O:5])[CH2:27][CH2:26]1)=[O:24])([CH3:21])([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 10377400Methyl 2-hydroxy-4-(2,2,2-trifluoroethoxy)benzoate

Product 1

HCID 68835888HCID 68835888, compoundYield 82.6%

Procedure

Using a procedure similar to that of Example 26-B, methyl 2-hydroxy-4-(2,2,2-trifluoroethoxy)benzoate (2.0 g, 7.99 mmol) is alkylated with 1-tert-butoxycarbonyl-4-hydroxypiperidine (1.61 g, 7.99 mmol) to afford methyl 2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(2,2,2-trifluoroethoxy)benzoate (2.86 g).

Sources & evidence

ORD record
ord-a02efbc475594085be6d4557b60f84e4
Source dataset
uspto-grants-2009_03
Patent number
US07511066B2

Reaction notes

Loading…