HCID 23024267, compound → HCID 178496131, compound

HRID 1787940Notes

Reaction equation

HRID 1787940 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]([O:12][CH2:13][CH2:14][O:15][CH3:16])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5].[C:17]([O:21][C:22]([NH:24][C@H:25]1[CH2:30][CH2:29][C@H:28](O)[CH2:27][CH2:26]1)=[O:23])([CH3:20])([CH3:19])[CH3:18]>CCOCC>[C:17]([O:21][C:22]([NH:24][C@@H:25]1[CH2:30][CH2:29][C@H:28]([O:1][C:2]2[CH:11]=[C:10]([O:12][CH2:13][CH2:14][O:15][CH3:16])[CH:9]=[CH:8][C:3]=2[C:4]([OH:6])=[O:5])[CH2:27][CH2:26]1)=[O:23])([CH3:20])([CH3:18])[CH3:19]

Participants

4

Reactant 2

HCID 23024267HCID 23024267, compoundHCID 178418329HCID 178418329, compound

Product 1

HCID 178496131HCID 178496131, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Using a procedure similar to that of Example 29-A, methyl 2-hydroxy-4-(2-methoxyethoxy)benzoate (6.0 g, 26.52 mmol) is alkylated with trans-4-tert-butoxycarbonylamino-cyclohexanol (5.38 g, 26.52 mmol) to afford the ether (2.70 g), which is used without further purification.

Workup

  1. customis used without further purification

Sources & evidence

ORD record
ord-a6b86e46d38b4a32807073ad18d93911
Source dataset
uspto-grants-2009_03
Patent number
US07511066B2

Reaction notes

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