Pyridine → HCID 87591830, compound

HRID 1787954Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([P:8]([C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)(=O)[OH:9])=[C:4]([CH3:19])[C:3]=1[CH3:20].N1C=CC=CC=1.S(Cl)([Cl:29])=O>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([P:8]([Cl:29])([C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:9])=[C:4]([CH3:19])[C:3]=1[CH3:20]

Participants

Conditions

Temperature: 0 °C

Procedure

250 g of the acid from Example 2 were suspended in 670 ml of toluene and dissolved with 102.6 g of pyridine. 1546 g of thionyl chloride were added dropwise to the reaction mixture at 60° C. over the course of 1 hour. After a post-reaction time of 3 hours, the red-brown emulsion was cooled to 0° C., and the rust-brown crystals were filtered off. The solution which remained was evaporated under reduced pressure.

Workup

filtrationthe rust-brown crystals were filtered off
customThe solution which remained was evaporated under reduced pressure

Sources & evidence

ORD record: ord-5ebcf41f0919404d881ce0e443e6e7e3
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07511084B2

Reaction notes

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