Ethylamine → HCID 798956, compound

HRID 1787985Notes

Reaction equation

HRID 1787985 reaction equation
[CH2:1]([NH2:3])[CH3:2].[C:4]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([S:14](Cl)(=[O:16])=[O:15])=[CH:10][CH:9]=1)(=[O:6])[CH3:5]>O1CCOCC1>[CH2:1]([NH:3][S:14]([C:11]1[CH:10]=[CH:9][C:8]([NH:7][C:4](=[O:6])[CH3:5])=[CH:13][CH:12]=1)(=[O:16])=[O:15])[CH3:2]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 8481N-Acetylsulfanilyl chloride

Product 1

HCID 798956HCID 798956, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
0 °C

Procedure

Ethylamine (0.0114 mMol) is added to a solution of 4-acetamidophenylsulfonyl chloride (1.34 g, 0.0057 mol) in dioxane (5 mL). The mixture is stirred for 1 hour at 0° C., then part of the solvent is removed by evaporation at reduced pressure, and water is added until precipitation of the resulting sulfonamide. The product is collected by filtration as a white solid in 48% yield and used without further purification.

Workup

  1. custompart of the solvent is removed by evaporation at reduced pressure, and water
  2. additionis added until precipitation of the resulting sulfonamide
  3. filtrationThe product is collected by filtration as a white solid in 48% yield
  4. customused without further purification

Sources & evidence

ORD record
ord-39fdb52fef834638aa3fde6b0ca316a4
Source dataset
uspto-grants-2009_03
Patent number
US07511133B2

Reaction notes

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