Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-Acetylsulfanilyl chloride | HCID 8481 | — |
| Reactant | Amantadine Hydrochloride | HCID 64150 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 2730602 | HCID 2730602 | 30.3% |
Reaction Steps
1-Adamantanamine hydrochloride (0.0114 mol) and triethylamine (0.0114 mol) are added to a solution of 4-acetamidophenylsulfonyl chloride (1.34 g, 0.0057 mol) in dioxane (5 mL). The mixture is heated for 1 hour at 80° C., then part of the solvent is removed by evaporation at reduced pressure, and water is added until precipitation of the resulting sulfonamide. The product is collected by filtration as a pink solid in 30.3% yield and used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07511133B2 |
|---|
| Source dataset | uspto-grants-2009_03 |
|---|
| ORD ID | ord-e4b6fae0c1e54924ac7ce671810fa5b1 |
|---|
| Source note | uspto-grants-2009_03 |
|---|
