HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1788057Generated: October 30, 2026
3-(3-Chlorophenyl)-alpha-(4-methylphenyl)-2,1-benzisoxazole-5-methanol → [3-(3-Chlorophenyl)-2,1-benzisoxazol-5-yl](4-methylphenyl)-methanone
https://huagongshe.com/reaction/1788057
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-(3-Chlorophenyl)-alpha-(4-methylphenyl)-2,1-benzisoxazole-5-methanol | HCID 17976101 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | [3-(3-Chlorophenyl)-2,1-benzisoxazol-5-yl](4-methylphenyl)-methanone | HCID 17976102 | 100% |
Reaction Steps
A mixture of intermediate 18 (0.071 mol) and MnO2 (0.287 mol) in 1,4-dioxane (250 ml) was stirred at 80° C. for 2 hours, then cooled to room temperature, filtered over celite and washed with DCM. The solvent was evaporated till dryness, yielding 24.7 g (100%) of [3-(3-chlorophenyl)-2,1-benzisoxazol-5-yl](4-methylphenyl)-methanone (intermediate 19).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07511138B2 |
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| Source dataset | uspto-grants-2009_03 |
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| ORD ID | ord-b8c3594ec5a64ca4a578b8f45428384d |
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| Source note | uspto-grants-2009_03 |
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