HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1788060Generated: October 30, 2026
Ammonium Acetate → 4-(3-chlorophenyl)-6-(4-methylbenzoyl)-2(1H)-quinazolinone
https://huagongshe.com/reaction/1788060
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | 2,2,2-trichloro-N-[2-(3-chlorobenzoyl)-4-(4-methylbenzoyl)phenyl]-acetamide | HCID 68689044 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-(3-chlorophenyl)-6-(4-methylbenzoyl)-2(1H)-quinazolinone | HCID 68687432 | 63.4% |
Reaction Steps
A mixture of intermediate 21 (0.0085 mol) and acetic acid, ammonium salt (0.0169 mol) in DMSO (42 ml) was stirred at 60° C. for 4 hours then cooled and poured out into ice water. The precipitate was filtered, washed with water, taken up in warm CH3CN, filtered off and dried under a vacuo, yielding 2.02 g (63%) of 4-(3-chlorophenyl)-6-(4-methylbenzoyl)-2(1H)quinazolinone (intermediate 22), mp. >260° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07511138B2 |
|---|
| Source dataset | uspto-grants-2009_03 |
|---|
| ORD ID | ord-ef68f45e67c84ed5b740f889c172e6d1 |
|---|
| Source note | uspto-grants-2009_03 |
|---|
