1,2-Dichloroethane → Methyl 6-methylpyridine-2-carboxylate

Participants

Reaction Conditions

Reaction Steps

To a suspension of 6-methyl-pyridine-2-carboxylic Acid (10 g, 72.9 mmol) in CH2Cl2 (200 mL) cooled to 0° C. is added MeOH (10 mL), 4-dimethylaminopyridine (11.6 g, 94.8 mmol), and EDC (18.2 g, 94.8 mmol). The mixture is stirred at RT for 6 h, washed with water and brine, and dried over Na2SO4. The mixture is filtered and concentrated in vacuo and the residue is chromatographed on silica gel (50% EtOAc/Hexanes) to yield the title compound, 9.66 g (92%), as a colorless liquid.

Provenance & Evidence