Hydrochloric Acid → HCID 11754658, compound

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Reaction Steps

Into a 100 mL roundbottom flask is placed 3-{4-[4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]phenyl}propionic Acid (Example 30 before reverse phase purification) (160 mg, 0.35 mmol), 20 mL of MeOH, and 1.5 mL of conc HCl solution. The mixture is refluxed 3 h, and solvent removed under reduced pressure. The product is partitioned between CH2Cl2 (20 mL) and saturated K2CO3 solution. The organic layer is collected and dried (MgSO4) and concentrated under vacuum. The title compound, 88.4 mg (54%), is crystallized from a concentrated CH2Cl2-Hexanes mixture.

Provenance & Evidence