Chloroform → HCID 86595275, compound

Participants

Reaction Steps

Manganese dioxide (507 g) was added to a solution of 61 g (0.25 mol) of 4-(2-hydroxyethylidene)azepane-1-carboxylic acid t-butyl ester obtained in the above 2) in a mixture of hexane (1865 ml)-chloroform (624 mL) and stirred for 18 hours. After the reaction was completed, insoluble materials were filtered off through Celite and the filtrate was concentrated under a reduced pressure to obtain 33.2 g (yield 55%) of 4-(2-oxoethylidene)azepane-1-carboxylic acid t-butyl ester (VII-17, 125, 126). Its physical property is shown below.

Provenance & Evidence