Chloroform → HCID 86595276, compound

Participants

Reaction Steps

Manganese dioxide (10 g) was added to a solution of 4-(2-hydroxyethylidene)-3,3-dimethylpiperidine-1-carboxylic acid t-butyl ester (0.9 g, 3.5 mmol) in a mixture of hexane (30 mL)-chloroform (10 mL) and stirred for 10 hours. After the reaction was completed, insoluble materials were filtered off through Celite, and the filtrate was concentrated under a reduced pressure to obtain 0.63 g (yield 70.8%) of 3,3-dimethyl-4-(2-oxoethylidene)piperidine-1-carboxylic acid t-butyl ester (VII-141, 142). Its physical property is shown below.

Provenance & Evidence